Molecular Testing of Thyroid Nodules: Optimizing patient care in 2024

Introduction

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In this lecture, we will explore the role of molecular testing in the evaluation and management of thyroid nodules. Emphasizing the advancements up to 2024, we will examine how molecular testing enhances diagnostic precision, reduces unnecessary surgeries, and supports personalized treatment strategies. Key topics will include the latest molecular markers, testing methodologies, and the integration of molecular testing into clinical practice to optimize patient care

Objectives

"By the end of the course learners will be able to :
1. Describe the latest techniques in molecular testing of thyroid nodules, including next-generation sequencing, gene expression classifiers, and mutation panels.
2. Evaluate the diagnostic accuracy and clinical performance of these molecular testing methods compared to traditional cytological analysis.
3. Explain how the incorporation of molecular testing into the diagnostic workup of thyroid nodules can improve risk stratification and guide appropriate clinical management.
4. Discuss how personalized treatment approaches informed by molecular profiling of thyroid nodules can lead to better patient outcomes, such as reduced rates of unnecessary surgeries.
5. Identify the key clinical scenarios where molecular testing of thyroid nodules provides the most value in optimizing patient care and decision-making.
6. Recognize the limitations and caveats of molecular testing, and the importance of interpreting results within the full clinical context.
7 Summarize the current guidelines and recommendations regarding the integration of molecular testing into the diagnostic algorithm for thyroid nodules.

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